FGF-1141 Featured on
ABC World News Tonight with Peter Jennings
6:30 p.m., May 12, 2004

Results from one of the human clinical trials for FGF-1141 were reported in this national news story about two patients who were treated at University of Cincinnati Hospital by Dr. Lynne Wagoner. Read the transcript here, or watch the News Clip now.



(Pre-story promos)
“In Medicine on the cutting edge tonight – in the fight against heart disease – growing new arteries from scratch.”

(Peter Jennings – promo)
“And at the end of the broadcast tonight, growing brand new arteries for a diseased heart, that is definitely medicine on the cutting edge.”

(Jennings – promo)
“When we come back, growing arteries, a very promising new treatment for people with heart disease.”

(Jennings)
“Finally from us this evening, medicine on the cutting edge. More than 6 million Americans suffer from angina or chest pains caused by a lack of blood flow to the heart. We’ve done reports on a variety of treatments which work for some people, but not for others - bypasses, stents and things like that. Tonight a report about doctors at the University of Cincinnati, who are providing blood to the heart in a very new way, here’s ABC’s Barry Serafin.”

(Reporter Barry Serafin)
“Despite three heart operations, including a quadruple bypass, Cincinnati mail carrier – James Duke, said he felt like an elephant was on his chest.”

(Voice over: James Duke)
“Constantly hurt, I’d be at home, I’d, ya know, I wanta get out and walk in the park and stuff like, I couldn’t do it, cause I’d get real tired.”

(Serafin)
“But since receiving an experimental treatment for his blocked arteries, his pain is gone.”

(Voice over: Duke)
“Now, I really feel great!”

(Serafin)
“Duke was one of the first heart patients in the country to be treated with a protein actually capable of growing brand new arteries. The genetically engineered protein is injected directly into the heart. [Hot link word “genetically engineered protein” to scientific overview page] Within days, a network of new vessels begins to grow around the blockage, increasing the blood supply. Dr. Lynne Wagoner showed us the changes in one patient’s heart.”

(Voice over: Dr. Lynne Wagoner)
“We see a small narrow main artery and not very many secondary and tertiary arteries; this is after the treatment, what were now seeing is new blood vessels growing here, off the end of this artery.”

(Serafin)
“And the patients themselves?”

(Wagoner)
“Symptomatically, they're improved within a couple of weeks of the treatment.”

(Serafin)
“Just ask Constance Donley”

(Voice over: Constance Donley)
“Oh, I feel wonderful; I’ve never felt so good in the last 5 years!”

(Serafin)
“The growth protein is still in the testing stage, but doctors already see potential in other cases where the blood supply needs a boost, such as strokes and diabetes.”

(Wagoner)
“It’s a very exciting, promising treatment for patients both with heart disease and other cardiovascular diseases.”

(Serafin)
“Tests have only been underway in this country for six months on a hand-full of patients, If they pan-out, the treatment could be available in three to four years. Barry Serafin, ABC News – Washington.”

Watch the ABC News Clip.

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